Imaging informatics

CT biomarkers, AI, and population health.

Research at the intersection of routine imaging, automated biomarker extraction, survival prediction, and safer radiology AI workflows.

The throughline is rigorous translation: harmonized cohorts, site-level quality control, cautious prediction language, and models that are useful because they are understandable.

CT biomarkers Radiology AI Multi-site validation Population health
People participating in a message crafting workshop at the Wisconsin Institute for Discovery.
Message crafting workshop · Wisconsin Institute for Discovery

Overview

Benjamin Rush, PhD, MPH is an informatics data scientist in the Department of Radiology at the University of Wisconsin–Madison whose research integrates CT-based biomarkers, large-scale imaging cohorts, and artificial intelligence to improve disease risk stratification and population health insight.

His work spans automated body composition analysis from abdominal CT, multi-site harmonization of imaging data, survival modeling, and the implementation of machine learning and large language models within radiology report workflows.

With training in epidemiology and nutritional sciences, he brings a translational lens to imaging informatics—connecting physiology, muscle and adipose tissue biology, and socioeconomic context to clinically actionable imaging biomarkers.

Across projects involving datasets bordering one million scans, he emphasizes reproducible pipelines, center-scale collaboration, and clear, empathetic science communication, operating under the philosophy that “with function comes beauty” in both computational systems and scientific discovery.

Full publication record on ORCID.

For scientific collaboration: rush4@wisc.edu

Research Projects

Radiology AI

LLMs for radiology reporting and incidental breast findings

I study how large language models can help identify incidental breast findings in radiology reports, with a focus on prompt design, model agreement, sensitivity, specificity, and consensus methods that could support safer follow-up workflows.

LLMs Prompt design Radiology reports

OSCAR

Multi-site CT biomarkers

I work on harmonizing opportunistic abdominal CT biomarkers across participating sites to evaluate generalizability, site-level robustness, and population-level prediction of survival and other outcomes. Biomarkers include L3 muscle area and density, SAT/VAT area, VAT density, visceral-to-subcutaneous fat ratio, L1 bone attenuation, and aortic calcium.

External validation Survival prediction Harmonization

Public health

Geospatial imaging context

I link CT-derived biomarkers with neighborhood-level socioeconomic indicators and healthcare access measures to study disparities and community-level patterns in imaging-derived health information.

Geospatial data Health equity Access

Body composition

Muscle, fat, bone, and function

I study muscle quantity, muscle density, adipose tissue distribution, bone attenuation, and longitudinal body composition change across clinical and population-level cohorts.

Muscle Adipose tissue Bone

Methods and rigor

I care about the parts of clinical data science that make models trustworthy: clear definitions, auditable data cleaning, appropriate statistics, and interpretation that matches the evidence.

Cohorts

Careful index CT logic

Define the index scan, deduplicate patients when needed, harmonize dates, align clinical variables, and preserve row-count audit trails through every major filtering step.

QC

Biomarker and site checks

Inspect medians, IQRs, ranges, missingness, implausible values, extraction failures, scanner/protocol variation, and site-level differences before modeling.

Modeling

Prediction with calibration

Use survival and fixed-horizon prediction approaches when appropriate, reporting discrimination, calibration, uncertainty, and clinically relevant operating characteristics.

Interpretation

Cautious clinical language

Frame findings as prediction, association, risk stratification, transportability, or external validation unless a diagnostic or causal claim has been specifically validated.

Publications

Journal of Clinical Densitometry · 2026

Novel DXA body composition approaches: comparison with traditional total body scans

Diane Krueger; Gretta Borchardt; Lucas Andersen; Benjamin Rush; Jevin Lortie; Adam J. Kuchnia; Jennifer Sanfilippo; Neil Binkley

View DOI

American Journal of Roentgenology · 2025

CT-Based Body Composition Measures and Systemic Disease: A Population-Level Analysis Using Artificial Intelligence Tools in Over 100,000 Patients

Pooler, B. Dustin; Garrett, John W.; Lee, Matthew H.; Rush, Benjamin E.; Kuchnia, Adam J.; Summers, Ronald M.; Pickhardt, Perry J.

View DOI

JCSM Communications · 2024

Uncorrected and subcutaneous fat-corrected echo intensities are similarly associated with magnetic resonance imaging per cent fat

Benjamin Rush; Sujay Garlapati; Jevin Lortie; Katie Osterbauer; Timothy J. Colgan; Daiki Tamada; Toby C. Campbell; Anne Traynor; Ticiana Leal; Kenneth Lee; et al.

View DOI

Journal of Cachexia, Sarcopenia and Muscle · 2022

The effect of computed tomography parameters on sarcopenia and myosteatosis assessment: a scoping review

Jevin Lortie; Grace Gage; Benjamin Rush; Steven B. Heymsfield; Timothy P. Szczykutowicz; Adam J. Kuchnia

View DOI

Dissertation · 2022

Using Bioimaging Techniques as Muscle Quality Biomarkers for Sarcopenia and Cachexia Diagnosis and Treatment

Benjamin Rush

View record

Frontiers in Rehabilitation Sciences · 2022

Myosteatosis as a Shared Biomarker for Sarcopenia and Cachexia Using MRI and Ultrasound

Benjamin Rush

View DOI

JBMR Plus · 2021

Combination of DXA and BIS Predicts Jump Power Better Than Traditional Measures of Sarcopenia

Benjamin Rush; Neil Binkley; Diane Krueger; Yosuke Yamada; Adam J Kuchnia

View DOI

The FASEB Journal · 2020

Identification of Muscle Wasting in Lung Cancer using MRI Proton Density Fat Fraction and Ultrasound

Katie Osterbauer; Jevin Lortie; Ben Rush; TJ Colgan; Kenneth Lee; Ticiana Leal; Scott Reeder; Adam Kuchnia

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Journal of Immigrant and Minority Health · 2016

Sexual Health and Language Dominance Among Hispanic/Latino Women and Men: Analysis of a Nationally Representative Sample

Lucia Guerra-Reyes; Benjamin Rush; Debby Herbenick; Brian Dodge; Michael Reece; Vanessa Schick; Stephanie A. Sanders; J. Dennis Fortenberry

View DOI